Antibodies for TDP43

New monoclonal antibodies are available to transactive response region DNA-binding protein 43 (TDP43) directed to different epitopes of N- and C-terminus as well as inside center of the molecule

 

Purified, in PBS w/0 additives, frozen at -20°C, 12 months shelf life. ELISA, WB, IHC, IF  

The transactive response region DNA-binding protein 43 (TDP43) binds both DNA and RNA and is involved in transcription and splicing. Under pathophysiological conditions, TDP43 accumulates in the cytoplasm and is hyperphosphorylated and/ or ubiquitinated, and this is Characteristic of the cytoplasmic inclusions observed in ALS and in many cases of frontotemporal labor degeneration syndrome (FTLD). Furthermore, TDP43 pathology is also detected in 20-50 %of AD patients, and appears to be associated with greater brain atrophy, memory loss, and cognitive impairment.

Sample Applications

Prominent physiological nuclear immunostaining of TDP43 and a neuronal cytoplasmic inclusion body in a neuron lacking the physiological nuclear staining (arrow) using 2G10 antibody in a case with FTLD-TDP (G.G. Kovacs, Toronto, Canada).

Fine neuropil threads in the hippocampus and neuronal cytoplasmic inclusions detected by 2G10 in an AD case with concomitant limbicTDP43 protein pathology (G.G. Kovacs, Toronto, Canada).

Order information

Order number

Unit (1/3)

Clon

Reactivity

clonality

847-0102007401/3

100 µg / 1 mg

2G10

TDP43 (200-220)

monoclonal

847-0102007701/3

100 µg / 1 mg

21B2

TDP43 (80-90)

monoclonal

847-0102007801/3

100 µg / 1 mg

19C9

TDP43 (80-90)

monoclonal

847-0102007901/3

100 µl / 1 ml

35G7

TDP43 (260-270)

monoclonal