Enzyme immunoassay for quantitative determination of a non-phosphorylated TAU fraction in human CSF supporting the diagnosis of Alzheimer’s disease
3.5 h protocol, 50 µl CSF required
The non-pTAU ELISA is an enzyme immunoassay intended for the quantitative determination of a tau fraction without (w/o) phosphor at T175/T181 in human CSF for supporting diagnosis of Alzheimer’s disease. The development of the Alzheimer’s disease is characterized by three stages, as defined by the US National Institute on Aging workgroups:
Tau w/o phosphor T175/T181 in CSF shows at least comparable diagnostic specificity and sensitivity to other diagnostic available tests for Alzheimer’s disease.
each laboratory must establish its own Cut-Off values
Mean signal negative control (blank) + 3xSD
AD/MCI patients (n=58)
Area under ROC-curve (AUC)