Antibodies for alpha-Synuclein

The portfolio includes antibodies against different sites of alpha-Synuclein as well as the pathological beta-sheet form of alpha-Synuclein.

 

Purified, in PBS w/0 additives, frozen at -20°C, 12 months shelf life. ELISA, WB, IHC, IF  

The portfolio includes antibodies for total, e.g. Anti-human α-synuclein 10D2, monoclonal as well as disease-specific α-synuclein. The anti-human α-synuclein 5G4, monoclonal antibody binds to pathologically relevant structures in neuropathology of Lewy body/ Parkinson’s disease and is capable of recognizing β-sheet-dependent epitope.

α-Synuclein is an abundant neuronal 140 amino acid protein, predominantly localized in the pre synaptic terminals, and involved in vesicle fusion and neurotransmitter release. Aggregates of α-synuclein are the main components of Lewy bodies (LB), which are intracellular inclusions characteristics of certain neurodegenerative diseases collectively referred to as α-synucleinopathies. These include Parkinson’s disease (PD), Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). However, α-synuclein aggregates are also found in approximately half of sporadic AD pathologies; consequently, it is crucial to differentiate it from pure AD forms.

Sample Applications

Specific detection of pathologic related structures by mab 5G4 in PD L. Coeruleus without un-specifically background staining (G.G. Kovacs et al. Acta Neuropath. 2012).

Specific detection of pathologic related structures by mab 5G4 in MSA without un-specifically background staining (G.G. Kovacs et al. Acta Neuropath. 2012).

Order information

Order number

Unit (1/3)

Clon

Reactivity

clonality

847-0102001801/3

100 µg / 1 mg

10C3

Human alpha-Synuclein

monoclonal

847-0102004001/3

100 µg / 1 mg

5G4

beta-sheet oligomers of human alpha-Synuclein

monoclonal

847-0102004701/3

100 µg / 1 mg

10D2

Human alpha-Synuclein

monoclonal

847-0103000901/3

100 µl / 1 ml

pAb 63

Human alpha-Synuclein

polyclonal