Antibodies for prions

Well established and tested antibodies to different binding sites of bovine and human prion protein are available

 

Purified, in PBS w/0 additives, frozen at -20°C, 12 months shelf life. ELISA, WB, IHC, IF  

Several human degenerative diseases resulted from misfolding and aggregation of proteins. The prototype central nervous system protein pathology is CJD, in which neuronal prion protein (PrP) with high α-helical content switches into a stable structure rich in β-pleated sheets in a self-catalyzing process that eventually causes a plethora of neurologic and psychiatric symptoms.

Sample Applications

Immunohistochemical detection of plaque-like deposits in perivacuolar areas of cortical greymatter and deep nuclei in sections from a patient of CJD using mab 14D11 (Navarro, Meixoeiro, Spain).

Immunohistochemical detection of fine synaptic accumulation in some nuclei such as the dentate nucleus of the cerebellum in sections from a patient with proven classic form of CJD using mab 14D11 (Navarro, Meixoeiro, Spain).

Order information

Order number

Unit (1/3) 

Clon

Reactivity

clonality

847-0102000701/3

100 µg / 1 mg

4F7

Bovine prion protein

monoclonal

847-0102000801/3

100 µg / 1 mg

1E5

Bovine prion protein

monoclonal

847-0102000901/3

100 µg / 1 mg

3E7

Bovine prion protein

monoclonal

847-0102001001/3

100 µg / 1 mg

3B8

Bovine prion protein

monoclonal

847-0102001101/3

100 µg / 1 mg

7B6

Bovine prion protein

monoclonal

847-0102001201/3

100 µg / 1 mg

5C4

Human prion protein

monoclonal

847-0102001301/3

100 µg / 1 mg

1E2

Human prion protein

monoclonal

847-0102001301/3

100 µg / 1 mg

6G3

Human prion protein

monoclonal

847-0102001601/3

100 µg / 1 mg

5B9

Human prion protein

monoclonal

847-0102004101/3

100 µg / 1 mg

6E2

Human prion protein

monoclonal

847-0102004201/3

100 µg / 1 mg

7D5

Human prion protein

monoclonal

847-0102004301/3

100 µg / 1 mg

5G11

Human prion protein

monoclonal

847-0102001704

100 µg / 1 mg

14D11

Human prion protein

monoclonal

847-0103000101/3

100 µl / 1 ml

pAb R10

Bovine prion protein

polyclonal