Several human degenerative diseases resulted from misfolding and aggregation of proteins. The prototype central nervous system protein pathology is CJD, in which neuronal prion protein (PrP) with high α-helical content switches into a stable structure rich in β-pleated sheets in a self-catalyzing process that eventually causes a plethora of neurologic and psychiatric symptoms.
Sample Applications
Immunohistochemical detection of plaque-like deposits in perivacuolar areas of cortical greymatter and deep nuclei in sections from a patient of CJD using mab 14D11 (Navarro, Meixoeiro, Spain).
Immunohistochemical detection of fine synaptic accumulation in some nuclei such as the dentate nucleus of the cerebellum in sections from a patient with proven classic form of CJD using mab 14D11 (Navarro, Meixoeiro, Spain).
Order information & data sheets
Order number | Size (1/3) | Clon (Data sheet) | Reactivity | clonality |
847-0102000701/3 | 100 µg / 1 mg | Bovine prion protein | monoclonal | |
847-0102000801/3 | 100 µg / 1 mg | Bovine prion protein | monoclonal | |
847-0102000901/3 | 100 µg / 1 mg | Bovine prion protein | monoclonal | |
847-0102001001/3 | 100 µg / 1 mg | Bovine prion protein | monoclonal | |
847-0102001101/3 | 100 µg / 1 mg | Bovine prion protein | monoclonal | |
847-0102001201/3 | 100 µg / 1 mg | Human prion protein | monoclonal | |
847-0102001301/3 | 100 µg / 1 mg | Human prion protein | monoclonal | |
847-0102001501/3 | 100 µg / 1 mg | Human prion protein | monoclonal | |
847-0102001601/3 | 100 µg / 1 mg | Human prion protein | monoclonal | |
847-0102004101/3 | 100 µg / 1 mg | Human prion protein | monoclonal | |
847-0102004201/3 | 100 µg / 1 mg | Human prion protein | monoclonal | |
847-0102004301/3 | 100 µg / 1 mg | Human prion protein | monoclonal | |
847-0102001704 | 50 µg | Human prion protein | monoclonal | |
| 847-0102003301/3 | 100 µg / 1 mg | 3F3 | Human prion protein | monoclonal |
| 847-0102003401/3 | 100 µg / 1 mg | 15F5 | Human prion protein | monoclonal |
847-0103000101/3 | 100 µl / 1 ml | Bovine prion protein | polyclonal |