Antibodies for forms of Tau protein and beta-Amyloid

Unique monoclonal antibodies (mab’s) and polyclonal sera againsts isoforms of Tau protein, phosphorylated and double-phosphorylated Tau protein as well as beta-Amyloid are available.

 

Purified, in PBS w/o additives, frozen at -20°C, 12 months shelf life. ELISA, WB, IHC, IF  

Tau is a microtubule-associated protein comprised of six human isoforms predominantly located in the axons of neurons. Neuronal and/or glial inclusions of tau can be detected in several neurodegenerative diseases or “tauopathies”, including Alzheimer’s disease (AD), frontotemporal lobar degeneration (FTLD), Pick’s disease, and cortico-basal degeneration (CBD) and Creutzfeldt-Jakob disease (CJD) may be characterized by their tau isoform profiles.

NEW Antibodies: Brain-derived Tau mAb 2B8 & p50 Tau mAb 15E3

CSF total Tau is a reliable Alzheimer’s disease-specific neurodegeneration marker. In contrast, plasma t-tau concentrations show large overlaps between diagnostic groups and do not correlate with CSF t-tau. Recent studies suggest, that plasma t-tau originates from peripheral, non-brain tissues. (Fernando Gonzalez-Ortiz, et al. Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration, Brain, Volume 146, Issue 3, March 2023, Pages 1152–1165, https://doi.org/10.1093/brain/awac407)

To solve this problem, we offer our brand-new Anti-human TAU total mab 2B8 that selectively binds to continuous exon 4-5 sequences on brain-derived Tau isoforms, but not to peripheral „Big Tau“ isoforms containing the exon 4a insert.

For more information take a look at this Flyer.

Hyperphosphorylation of the neuronal tau protein is a hallmark of neurodegenerative tauopathies such as Alzheimer’s disease. New research suggests, that a few master phosphorylation sites - T50, T69, T111, T181, and T205 – trigger hyperphosphorylation of tau after they have been initially phosphorylated. (Stefanoska Ket al. Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation. Sci Adv. 2022 Jul 8;8(27):eabl8809. doi: 10.1126/sciadv.abl8809)

Our antibody Anti-human phospho-50 TAU mab 15E3 specifically binds human TAU phosphorylated at amino acid position 50 (Thr) and has the potential to distinguish AD from control patients.

For more information take a look at this Flyer.

Sample Applications

Specific detection of P231 tau in astrocytic plaques from Alzheimer's patients using mab 4C10 (G.G. Kovacs, Toronto, Canada).

Specific detection of astrocytic plaques using mab 9D8 in brain of patient with Alzheimers disease (G.G. Kovacs, Toronto, Canada).

Detection of β-amyloid pathological related deposits in Cortex tissue of a patient suffering from Alzheimer’s disease using mab 6D11 (S. Rossner, Leipzig, Germany).

Order information & data sheets

Order number

  Size (1/3)

Clon

(Data Sheet)

Reactivity

Clonality

847-0102003801/3

100 µg/1 mg

1E7

phospho-Tau (Thr181)

monoclonal

847-0102003901/3

100 µg/1 mg

8B11

phospho-Tau (Thr181)

monoclonal

847-0102006201/3

100 µg/1 mg

8D2

phospho-Tau (Thr181)

monoclonal

847-0102006101/3

100 µg/1 mg

10D3

phospho-Tau (Thr181)

monoclonal

847-0102008601/3

100 µg/1 mg14B6phospho-Tau (Thr181)monoclonal

847-0102003201/3

100 µg/1 mg

1F3

phospho-Tau (Ser199)

monoclonal

847-0102004601/3

100 µg/1 mg

9C8

phospho-Tau (Ser199+Ser202)

monoclonal

847-0102004501/3

100 µg/1 mg

10F8

phospho-Tau (Ser202)

monoclonal

847-0102003501/3

100 µg/1 mg

2B11

phospho-Tau (Thr231)

monoclonal

847-0102003601/3

100 µg/1 mg

5G7

phospho-Tau (Thr231)

monoclonal

847-0102003701/3

100 µg/1 mg

9D8

phospho-Tau (Thr231)

monoclonal

847-0102003101/3

100 µg/1 mg

4C10

phospho-Tau (Thr231)

monoclonal

847-0102004401/3

100 µg/1 mg

3G3

phospho-Tau (Thr231+Thr235)

monoclonal

847-0102008001/3

100 µg/1 mg15E3phospho-Tau (Thr50)monoclonal

847-0102007601/3

100 µg/1 mg2B8Brain-derived Taumonoclonal

847-0102004801/3

100 µg/1 mg

4B5

Tau-441 (2N4R)

monoclonal

847-0102005101/3

100 µg/1 mg

8F10

Tau-441 (2N4R)

monoclonal

847-0102005201/3

100 µg/1 mg

12C2

Tau-441 (2N4R)

monoclonal

847-0102005301/3

100 µg/1 mg

18B5

Tau-441 (2N4R)

monoclonal

847-0102006301/3

100 µg/1 mg

7E5

Tau all isoforms

monoclonal

847-0102007501/3100 µg/1 mg1G2

Tau w/o phosphor T175/T181

monoclonal
847-0102007601/3100 µg/1 mg2B8

Tau all isoforms

monoclonal

847-0102006401/3

100 µg/1 mg

2B6

Exon 3 human tau

monoclonal

847-0102006601/3

100 µg/1 mg

9E11

Exon 2 and 3 human tau

monoclonal

847-0103001001/3

100 µl /1 ml

pAb 64

Tau-441 (2N4R)

polyclonal

847-0102006501/3

100 µg/1 mg

6D11

beta-Amyloid

monoclonal

847-0102008401/3100 µg/1 mg2C7beta-Amyloid 1-12

monoclonal

847-0102008501/3100 µg/1 mg3C4beta-Amyloid 1-12

monoclonal

847-0102008901/3

100 µg/1 mg22C2beta-Amyloid 42monoclonal